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Critical Thinking in Critical Care Medicine


NICE-SUGAR study-Intensive Blood Glucose control in an ICU might be associated with increased mortality.
Find the original article here https://www.nejm.org/doi/0full/10.1056/NEJMoa0810625 Author: Peter Ryu Tofts, MD Editor: Martin M....

Peter Tofts, MD
Feb 144 min read
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BICAR-ICU trial: in a subgroup with severe acidemia and severe Acute Kidney Injury a bicarbonate infusion reduces need for renal replacement therapy and potentially mortality at 28 days.
Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre,...

David Goldenberg, DO
Jan 24 min read
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Vanish 2 trial: VT Ablation first strategy does not improve patient important outcomes in clinically significant ventricular tachycardia. Critical Appraisal.
Vanish 2 Trial Critical Appraisal by Tooba Shaukat Butt, MD. Edited by Martin M. Cearras, MD, FACP. Find the original article here! h...
Martin Cearras, MD
Dec 27, 20243 min read
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Leuven I trial - Intensive Blood Glucose control in a Cardiovascular and Surgical ICU is associated with a decrease in mortality and improved secondary outcomes.
Author: Peter Tofts, MD; Edited: Martin Cearras, MD Find the original article here! Intensive Insulin Therapy in Critically Ill Patients...
Martin Cearras, MD
Dec 15, 20242 min read
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STARRT - AKI trial. Harm and unnecessary Renal Replacement Therapy (RRT) when RRT is started early in the ICU.
Critical Appraisal of the Starrt - AKI trial for early renal replacement in the ICU

Peter Tofts, MD
Oct 22, 20243 min read
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Reduce Trial
Find the original article below! Short-term vs Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Obstructive...
Martin Cearras, MD
Oct 17, 20242 min read
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Clovers Trial:
Find the original article below! Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension | New England Journal of...
Martin Cearras, MD
Oct 16, 20242 min read
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Classic Trial
Standard vs Restrictive Fluid Administration Restriction of Intravenous Fluid in ICU Patients with Septic Shock | New England Journal of...
Martin Cearras, MD
Oct 16, 20242 min read
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Acorn Trial
Cefepime vs Piperacillin-Tazobactam in adults hospitalized with acute infections Find the original article! Cefepime vs...
Martin Cearras, MD
Oct 16, 20242 min read
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Fresh Trial
Find the original article here!  Fluid Response Evaluation in Sepsis Hypotension and Shock - CHEST ( chestnet.org ) Summary: The “Fresh...
Martin Cearras, MD
Oct 16, 20243 min read
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Enhancing Evidence-Based Practice in Critical Care Medicine
As healthcare professionals in the field of critical care medicine, one of our most important responsibilities is making sound clinical...
Martin Cearras, MD
Sep 21, 20242 min read
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