Welcome to Our Site

At Critical Thinking in Medicine, we empower healthcare professionals with the skills to apply evidence-based medicine effectively. Join us in enhancing your medical knowledge and improving patient outcomes through critical appraisals of the literature and joint informed decision-making.

Become a lifelong learner and a teacher. Apply your newfound skills and knowledge to enhance patient care.

Explore Our Resources and Enhance Your Journal Club Leading Skills

We are Empowering Medical Professionals

Latest Literature Critical Appraisals:

General Evidence Based Medicine Concepts:

Not all positive outcomes are created equal!

Beware of the trials with multiple secondary or tertiary outcomes.

Throwback to picking teams for dodgeball...

Let's talk Allocation Concealment and Selection Bias.

Are my results robust or fragile?

Fragility index

Outcomes in Journal Articles

How to avoid under or over-estimating effects on our patients, when they are shown in different ways.

The Rise of the Win Ratio.

Is Time Up for the Traditional Composite Outcome Approach?

Study Design... Why would that matter?!

Understanding validity and risk of bias in published journal articles.

Why do EBP people keep insisting on Randomization? I can already see that my device works!

Understanding how randomized trials are superior to observational studies

Library of Journal Club Articles

Critical Care Articles

Summaries of specialty specific articles,

new and landmark.

Internal Medicine Articles

Summaries of specialty specific articles,

new and landmark.

Types of Studies
(under Construction)
Topics in blue are linked explanations.

Randomized controlled trial

Basic Topics: Randomization. Allocation Concealment. Blinding. Intention-to-treat analysis. Loss to follow up. Measures of outcomes. Precision and Accuracy of Outcomes. Stopping trials early. Composite outcomes.

Advanced Topics: Non-inferiority trial. Per protocol Analysis. As treated analysis. Win ratio.

Systematic Reviews

Basic Topics: Comprehensive Search Strategy. Forest Plots. Heterogeneity. Meta-analysis of data. Funnel Plots and publication bias.

Advanced topics: Random effects vs. Fixed Effects models

Cohort Studies

Basic Topics: Cohort study design. Diagnostic test characteristics - Sensitivity and Specificity. Pre-test probability. Likelihood Ratios. Action Thresholds. Fagan Nomogram.

Advanced Topics: Agreement beyond Chance.

Case Control Studies

Basic Topics: Case control design.

Advanced Topics: Odds Ratios vs Risk Ratios. Correlation and Regression.

Pubmed

Search the Medline database for published primary Literature.

Cochrane Library

Systematic Reviews and Meta-analyses, following strict validity criteria

ACP Journal Club

Pre-appraised primary Literature

TIPS articles

Articles exploring Evidence Based teaching scripts for teaching Evidence Based Medicine

Meet the Team

Our expanding team is made up of passionate faculty from a variety of institutions, all united by their excitement for learning and teaching Evidence-Based Medicine!

Admin, Blogger and EBM enthusiast

Martin Cearras, MD, FACP.

Martin Cearras is a Pulmonary & Critical Care Medicine trained physician with almost 20 years of experience. He is an enthusiast of Evidence Based Medicine and enjoys teaching and discussing evidence with his trainees and patients. He was an invited tutor at the DUKE EBM workshop for over a decade.

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Blogger and EBM enthusiast

Peter Ryu Tofts, MD

Dr. Tofts is a Pulmonary & Critical Care Medicine trained physician. He has attended the Duke Evidence Based Medicine workshop and has adopted EBP to his daily practice .

Blogger and EBM enthusiast

David Goldenberg, DO

Dr. Goldenberg is an Internal Medicine and Critical Care Medicine Trained Physician. He was a junior faculty at the Duke EBM workshop. His main interests include hematological malignancies in the ICU

About Our Mission

Our Vision

Critical Thinking in Medicine is a dedicated online platform committed to advancing evidence-based medicine teaching. Our goal is to provide medical professionals with the necessary resources to navigate research studies effectively, fostering critical thinking skills and promoting unbiased practices in medicine in general, and particularly in critical care. Join us in our mission to enhance patient care through informed decision-making and evidence-based practices.

Welcome to Our Site

Latest Literature Critical Appraisals:

NICE-SUGAR study-Intensive Blood Glucose control in an ICU might be associated with increased mortality.

BICAR-ICU trial: in a subgroup with severe acidemia and severe Acute Kidney Injury a bicarbonate infusion reduces need for renal replacement therapy and potentially mortality at 28 days.

Vanish 2 trial: VT Ablation first strategy does not improve patient important outcomes in clinically significant ventricular tachycardia. Critical Appraisal.

General Evidence Based Medicine Concepts: